75N92018D00010

JACKSON HEART STUDY - THE GOAL OF THIS ACQUISITION IS TO PROVIDE A COORDINATING CENTER TO CONTINUE TO MAXIMIZE THE USE OF DATA AND SAMPLES AMASSED ON THE JACKSON HEART STUDY (JHS) COHORT AND TO ADDRESS NEW QUESTIONS ABOUT THE DEVELOPMENT AND PROGRESSION OF CLINICAL CARDIOVASCULAR DISEASE (CVD) AND RELATED CONDITIONS. THE SCIENTIFIC OBJECTIVES ARE TO (1)INVESTIGATE FACTORS THAT ACCOUNT FOR THE HIGH BURDEN OF CVD IN AFRICAN- AMERICANS, WITH SPECIFIC FOCUS ON FACTORS RELATED TO VENTRICULAR DYSFUNCTION AND HEART FAILURE AND IMPAIRED COGNITIVE FUNCTION; AND (2) IMPROVE STATISTICAL POWER FOR FURTHER RISK PREDICTION AND HYPOTHESIS TESTING, PARTICULARLY IN INFORMATIVE SUBGROUPS. THE OPERATIONAL GOALS ARE TO(1) CONTINUE TO FOSTER SCIENTIFIC COLLABORATIONS; WORK COLLABORATIVELY TO (2) PROVIDE COHORT FOLLOW-UP AND CLINICAL EVENTS ASCERTAINMENT ACTIVITIES; (3) CONDUCT A CLINIC EXAMINATION OF THE JHS PARTICIPANTS; (4) PROMOTE CARDIOVASCULAR HEALTH IN THE LOCAL COMMUNITY; AND (5) ENCOURAGE UNDERREPRESENTED MINORITY STUDENTS TO PURSUE BIOMEDICAL CAREERS.