75N92018D00011

THE GOAL OF THIS ACQUISITION IS TO PROVIDE A FIELD CENTER TO CONTINUE CONTACT WITH AND DATA COLLECTION IN THE JHS COHORT TO ADDRESS NEW QUESTIONS ABOUT THE DEVELOPMENT AND PROGRESSION OF CLINICAL CVD AND RELATED CONDITIONS. THE SCIENTIFIC OBJECTIVES ARE TO (1) INVESTIGATE FACTORS THAT ACCOUNT FOR THE HIGH BURDEN OF CVD IN AFRICAN- AMERICANS, WITH SPECIFIC FOCUS ON FACTORS RELATED TO VENTRICULAR DYSFUNCTION AND HEART FAILURE AND IMPAIRED COGNITIVE FUNCTION; AND (2) IMPROVE STATISTICAL POWER FOR FURTHER RISK PREDICTION AND HYPOTHESIS TESTING, PARTICULARLY IN INFORMATIVE SUBGROUPS. THE OPERATIONAL GOALS ARE TO (1) CONTINUE TO FOSTER SCIENTIFIC COLLABORATIONS; 2) CONDUCT COHORT FOLLOW-UP AND CLINICAL EVENTS ASCERTAINMENT ACTIVITIES; AND (3) CONDUCT A CLINIC EXAMINATION OF THE JHS PARTICIPANTS; AND (4) PRODUCE AND DISSEMINATE RESEARCH FINDINGS TO SCIENTIFIC AND LAY COMMUNITIES.